| Autor: |
Stewart, David, Richard, Michael, Benoit, Brien, Hugenholtz, Herman, Russell, Neville, Dennery, Jean, Peterson, Eric, Grahovac, Zev, Belanger, Garry, Aitkens, Susan, Young, Vincent, Maroun, Jean |
| Zdroj: |
Journal of Neuro-Oncology; Mar1984, Vol. 2 Issue 1, p29-34, 6p |
| Abstrakt: |
A combination of cisplatin and cytosine arabinoside was used to treat 21 patients with glioblastomas and 5 patients with recurrent grade 11 gliomas. Cisplatin 60-100 mg/m was given I.V. in 250 ml 0.45% saline and preceded by 500 ml dextrose 5% in 0.45% saline. Mannitol 50 g was given I.V. concurrently with the cisplatin. Cytosine arabinoside 500-1000 mg/m was given by rapid I.V. infusion immediately after the cisplatin. Of 25 evaluable patients, 10 (40%) experienced objective tumor shrinkage on CT scan, and 6 (24%) stabilized. There were 2 complete remissions. Patients who had had no prior treatment had a higher response rate (58%) than those previously treated (23%). Myelosuppression occurred in some patients 2-3 weeks after treatment. Gastrointestinal toxicity (vomiting and diarrhea) was dose-limiting. Two patients had possible neurological toxicity. Recommended doses for further studies are cisplatin 90 mg/m and cytosine arabinoside 900 mg/m. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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