| Autor: |
Nikitin, V., Lazhetich, B., Baich, M., Sherstnev, V. |
| Zdroj: |
Neurophysiology; Sep1987, Vol. 19 Issue 5, p471-478, 8p |
| Abstrakt: |
The possible role of S-100 brain specific proteins and their involvement in the neuronal mechanisms of habituation were investigated in identified neurons of the snail ( Helix pomatia). Extracellular application and intracellular injection of antibodies into S-100 proteins caused a rapid and significant reduction of neuronal response to repeated stimulation compared with the control. A considerable reduction in the amplitude of evoked EPSP and an increase in the duration of latency of potentials was produced by the antibodies and numbers of action potentials declined. Meanwhile, membrane potential, membrane input impedance, and neuronal pacemaker potentials remained virtually unchanged. This effect is presumed to occur due to breakdown of synaptic transmission processes. The subject of possible involvement of S-100 proteins in the operation of synaptic structures as a primary apparatus for integrating neuronal activity is considered. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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