Ganglioside-cholera toxin interactions: a binding and lipid monolayer study.

Autor: Cumar, F., Maggio, B., Caputto, R.
Zdroj: Molecular & Cellular Biochemistry; Aug1982, Vol. 46 Issue 3, p155-160, 6p
Abstrakt: On t.l.c. plates I-cholera toxin binds to a disialoganglioside tentatively identified as GD with about 10 times less capacity than to ganglioside GM. Binding of labeled toxin to both gangliosides was abolished in presence of excess amounts of unlabeled B subunit. Ganglioside extracts from human or pig intestinal mucosa showed toxin binding to gangliosides GM and GD. In ganglioside-containing lipid monolayers the penetration of the toxin was independent of the ganglioside binding capacity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index