| Autor: |
Igarashi, Takashi, Sekine, Yuriko, Kawato, Hidehiko, Kamoshita, Shigehiko, Saigusa, Yoshindo |
| Zdroj: |
Pediatric Nephrology; May1992, Vol. 6 Issue 3, p267-269, 3p |
| Abstrakt: |
We describe a neonate with distal renal tubular acidosis with secondary hyperparathyroidism manifesting as hyperchloraemia, hypercalcaemia, elevated serum parathyroid hormone (PTH) and life-threatening metabolic acidosis. He exhibited general weakness, tachypnoea, dry skin and weight loss. Urinary excretion of titratable acid and ammonium was decreased. Daily alkali (2.5 mEq/kg body weight) was required to maintain a normal plasma bicarbonate (HCO−). With alkali therapy, the fractional excretion of HCO− was below 5%. Serum calcium and PTH were restored to normal promptly on initiation of alkali therapy. After 5 months of alkali therapy, normal growth and urine acidifying ability were restored and alkali therapy was discontinued. The acidification defect in this patient was transient. We consider this patient to be consistent with Lightwood's syndrome of 'transient infantile renal tubular acidosis'. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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