| Autor: |
Sutter, Paul, Thulin, Gunilla, Stromski, Michael, Ardito, Tom, Gaudio, Karen, Kashgarian, Michael, Siegel, Norman |
| Zdroj: |
Pediatric Nephrology; Mar1988, Vol. 2 Issue 1, p1-7, 7p |
| Abstrakt: |
To evaluate the effect of thyroxin (T) on recovery from ischemic acute renal failure, rats were treated with T (10 or 20 μg/100 g body wt.) or normal saline (NS) either immediately prior to, immediately after or 24 h after 45 min of renal ischemia. Animals given T prior to ischemia had no significant increase in Inulin clearance (C) (377±40 μl/min per 100 g body wt.) as compared with saline-treated ischemic controls (306±54). In contrast, animals treated immediately after ischemia with either dose of T demonstrated significantly better kidney function (C 515±59 μl/min per 100 g body wt., U 842±88 mosmol/kg, FE 0.52%±0.12% and C 543±71, U 939±103, FE 0.48±0.12, for 10 and 20 μg/100 g body wt., respectively). Moreover, the improvement in renal function was sustained and C was significantly better at day 3 (748±70) and day 7 (990±75) compared with saline controls (560±30 and 732±45, respectively). Animals which received T 24 h after ischemia showed significantly higher C when compared with ischemic controls. To assess the impact of T on recovery of renal ATP,P-NMR was used. T-treated rats demonstrated 90%±5% recovery of renal ATP by 120 min of reflow, whereas NS animals had only 64%±1%. In addition, cellular morphology was better preserved in T animals. These data indicate that animals treated postischemically with T showed accelerated and sustained recovery from acute renal failure. This beneficial effect appears to be related to cellular mechanisms which are essential for the restoration of sublethally injured cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink