| Autor: |
Nowak, Ireneusz, Damaraju, Vijaya I., Cass, Carol E., Young, James D., Robinsa, Morris J. |
| Předmět: |
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| Zdroj: |
Collection of Czechoslovak Chemical Communications; 2011, Vol. 76 Issue 12, p1395-1412, 18p, 1 Color Photograph, 4 Diagrams, 1 Chart, 1 Graph |
| Abstrakt: |
Nucleosides with an aromatic five-membered ring heterocycle (N, O, or S) fused at C4-C5 of pyrimidin-2-one were prepared by ring closures with 5-(alkyn-1-yl)pyrimidin-2-one intermediates, heterocyclic atom replacements, and ring closure with a 5-aminocytidine derivative. Ultraviolet absorption and emission properties of the autofluorescent products enabled studies on permeation and inhibition of the trans-cellular trafficking effected by human equilibrative nucleoside transporters (hENTs). Some of the autofluorescent nucleosides were shown to be potent and selective inhibitors of human concentrative nucleoside transporters (hCNTs) in a companion study reported elsewhere. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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