| Autor: |
Punzengruber, Ch., Silberbauer, K. |
| Zdroj: |
Basic Research in Cardiology; May1986, Vol. 81 Issue 3, p283-288, 6p |
| Abstrakt: |
Angiotensin Il's influence on circulating levels of prostaglandin I metabolite 6-keto-PGF were determined during a pharmacological stress test of left ventricular function in 10 control subjects and 5 patients with coronary artery disease. Angiotensin II infusion (1.5±0.34 μg/min) led to a significant increase of mean arterial blood pressure in both study groups (p<0.001). Heart rate decreased in control subjects (p<0.01) whereas in patients with coronary artery disease no significant change occurred. Global left ventricular ejection fraction determined by gated blood pool scanning decreased significantly in both study groups (p<0.05). The lack of reflex bradycardia in patients with coronary artery disease may be due to a compensatory increased sympathetic tone, prohibiting a more pronounced decline in ejection fraction. 6-keto-PGF levels could be measured only in 6 of 15 persons. In the others they were below the limit of detection of the assay (70 pg/ml). During angiotensin II infusion 6-keto-PGF increased significantly and could be determined in all persons. Patients with coronary artery disease reached slightly higher 6-keto-PGF levels than controls (119±19 pg/ml versus 91.5±7 pg/ml; n.s.). Thus although angiotensin II infusion leads to vasoconstriction and increases peripheral resistance it also stimulates the production of vasodilating prostaglandins which may play a role in preserving microcirulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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