| Autor: |
Shuter, S., Bernier, M., Davies, M., Kusama, Y., Takahashi, A., Slater, T., Hearse, D., Garlick, P. |
| Zdroj: |
Basic Research in Cardiology; Jul1989, Vol. 84 Issue 4, p421-430, 10p |
| Abstrakt: |
Antioxidants that act as free radical scavengers have the potential to inhibit lipid peroxidation. It has previously been proposed that a relationship exists between free radicals, lipid peroxidation and reperfusion-induced arrhythmias. We have therefore examined the ability of the lipid-soluble antioxidant, alpha-tocopherol, to decrease the incidence of reperfusion-induced arrhythmias. We have shown that the myocardial alpha-tocopherol content can be significantly increased from its control value of 65.3±5.6 nmoles/g wet wt of heart to 115.0±15.6 nmoles/g wet wt of heart (p<0.01) by chronic intraperitoneal pretreatment and that it can be decreased, to 21.1±3.7 nmoles/g wet wt of heart (p<0.01), by chronic dietary manipulation. Rat hearts isolated from either of these groups, or from placebo-treated control animals, were subjected to 5 or 10 min coronary artery occlusion and were subsequently reperfused; there were no significant differences between the incidence and duration of VF and VT or the incidence and number of VPBs in these three groups. The effect of alpha-tocopherol manipulation on metabolic and functional recovery of working hearts subjected to 20 min global ischemia was subsequently examined and no significant changes were observed. Cardiac output recovered to 82±4, 81±6 and 76±5% of its preischemic value in the control, enriched and depleted groups, respectively. In conclusion, myocardial alpha-tocopherol content appears to bear no relation to the severity of reperfusion-induced arrhythmias or to the resistance of the heart to ischemic injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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