Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.

Autor:	Erttmann, R., Bielack, S., Landbeck, G.
Předmět:	ANTINEOPLASTIC agents ASPARTATE aminotransferase COMPARATIVE studies DYNAMICS FOLINIC acid RESEARCH methodology MEDICAL cooperation METHOTREXATE OSTEOSARCOMA RESEARCH EVALUATION research ALANINE aminotransferase RETROSPECTIVE studies
Zdroj:	Cancer Chemotherapy & Pharmacology; Aug1985, Vol. 15 Issue 2, p101-104, 4p
Abstrakt:	Kinetics of 7-hydroxy-methotrexate (7-OH-MTX) excretion after high-dose methotrexate (MTX) (12 g/m2) therapy were monitored in 93 consecutive drug cycles of 19 adolescent patients with osteosarcoma. A reversed-phase HPLC method was used. Serum elimination was found to be monophasic with a mean half-life of 5.5 h. Shortly after the 4-h MTX infusion period 7-OH-MTX levels exceeded those of the parent compound. By 12 h after MTX infusion 7-OH-MTX levels were 16.5 times higher than those of MTX itself. Autostimulation of MTX metabolism leading to enhanced 7-OH-MTX production after repeated drug cycles was not observed. The production of 7-OH-MTX decreased significantly from the first to the last high-dose MTX cycle of the adjuvant chemotherapy protocol. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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