| Autor: |
Gandara, D., Ries, C., Schiff, S., George, C., Lewis, J., Koretz, M., Carter, S., Gandara, D R, Ries, C A, Schiff, S A, George, C B, Lewis, J P, Koretz, M M, Carter, S K |
| Předmět: |
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| Zdroj: |
Cancer Chemotherapy & Pharmacology; Sep1982, Vol. 9 Issue 1, p10-12, 3p |
| Abstrakt: |
Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis. Disease subsets consisted of patients with acute non-lymphocytic leukemia (ANLL) over age 60; ANLL refractory to standard therapy; smouldering leukemia; and refractory anemia with excess blasts (RAEB). In agreement with previous studies, toxicity from Prednimustine was relatively mild, consisting primarily of infrequent myelosuppression, gastrointestinal side-effects, and mild hyperglycemia. This study did not, however, confirm previously reported remission rates in ANLL: in 41 evaluable patients only two complete remissions were achieved. Both occurred in the subset of patients with smouldering leukemia. We conclude that Prednimustine has limited activity in this patient population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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