| Autor: |
Peest, Dietrich, Vries, Ina, Hölscher, Regina, Leo, Regine, Deicher, Helmuth |
| Zdroj: |
Cancer Immunology, Immunotherapy; Jul1989, Vol. 30 Issue 4, p227-232, 6p |
| Abstrakt: |
Short-term cultures containing bone marrow mononuclear cells from multiple myeloma patients secrete monoclonal immunoglobulin and β-microglobulin into the supernatant, which can be measured quantitatively in an enzyme-linked immunosorbant assay. In this system, the addition of interleukin-2 was shown to induce tumor cell regression in the cultures from 10 out of 14 multiple myeloma patients in a dose-dependent manner. Marker analyses of culture cell populations indicate that OKT3 antibody or interleukin-2 did not directly act on the malignant clone but augmented autologous T lymphocytes, which were responsible for the regression of tumor cells in the cultures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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