| Autor: |
Emken, E., Dutton, H., Rohwedder, W., Rakoff, Henry, Adlof, R., Gulley, R., Canary, J. |
| Zdroj: |
Lipids; Oct1980, Vol. 15 Issue 10, p864-871, 8p |
| Abstrakt: |
Triglycerides containing cis- and trans-12-octadecenoic acid (12 c-18∶1 and 12 t-18∶1) and cis-9-octadecenoic acid (9 c-18∶1) labeled with deuterium were fed to 2 young adult male subjects. These fatty isomers each contained a different number of deuterium labels, which allowed mass spectrometric analysis to distinguish among them after they were fed as a mixture. This approach results in a direct comparison of the absorption and distribution of these 3 monoenoic acids into blood plasma and lipoprotein lipids. Plasma lipid data indicated that all phospholipid fractions selectively incorporate 12 c-18∶1 and 12 t-18∶1 in preference to 9 c-18∶1. Discrimination against 12 c-18∶1 and 12 t-18∶1 compared to 9 c-18∶1 was found in the plasma neutral lipids, with a strong discrimination against 12 t-18∶1 incorporation into the cholesteryl ester fraction. Considerable reduction in the percentage of linoleic and arachidonic acid was observed when 12-18∶1 isomers were incorporated in plasma triglyceride, phosphatidylcholine and sphingomyelin samples. Chylomicron lipid analyses indicated that all isomers were well absorbed. Variation was observed in the relative distribution of 12 c-18∶1, 12 t-18∶1 and 9 c-18∶1 between the very low density, low density and high density lipoprotein lipid classes. No desaturation of 12 c-18∶1 to linoleic acid was detected. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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