| Abstrakt: |
To most fully explicate risk to coronary heart disease (CHD) in adults and children with elevated plasma total cholesterol, the levels of high and low density lipoprotein cholesterol (C-HDL, C-LDL) must be quantitated. This report focuses upon C-HDL and C-LDL levels in children identified in a lipid and lipoprotein sampling survey of 6,775 Princeton School children, by either total plasma cholesterol ≥205 mg/dl, the approximate 95th percentile for children 6-17 years of age, or age-, sex-, and race-specific 95th percentiles for cholesterol. Using the sex-, race-specific local 95th percentiles for C-HDL and C-LDL, the hypercholesterolemic children were separated into four categories according to whether they had elevations of both C-HDL and C-LDL, C-HDL only, C-LDL only, or neither. When selection for hypercholesterolemia was based on the overall 95th percentile (205 mg/dl), black children were more likely than white to have elevations of C-HDL only, which accounted for their hypercholesterolemia, p<.05, whereas white children were much more likely to have elevations of C-LDL only, than were black children, p<.005. However, when selection for hypercholesterolemia was based on age-, sex-, and race-specific 95th percentile cholesterol levels, there were no differences in the proportion of black and white children having elevations of C-HDL and C-LDL, accounting for their hypercholesterolemia. Elevated levels of C-HDL can explain apparent hypercholesterolemia in at least 16% of children, ages 6-17, who may putatively be at reduced, rather than increased CHD risk. [ABSTRACT FROM AUTHOR] |
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