In vitro studies on interaction of rat pancreatic lipase and colipase with biliary lipids.

Autor:	Lairon, D., Nalbone, G., Domingo, N., Lafont, H., Hauton, J., Julien, R., Rathelot, J., Canioni, P., Sarda, L.
Zdroj:	Lipids; Apr1975, Vol. 10 Issue 4, p262-265, 4p
Abstrakt:	Lipase and colipase were prepared separately from rat pancreatic juice, and their respective interaction with biliary lipids was investigated by gel filtration on agarose in the presence of a micellar solution of sodium taurocholate. It was found that the cofactor can associate with the biliary lipids, whereas the enzyme forms a high mol wt complex only in the presence of colipase. It is suggested that biliary phospholipids might participate in the in vivo formation of the enzyme-cofactor substrate complex at the triglyceride-water interface in the presence of bile salts. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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