| Autor: |
Teng, Hao-Wei, Hsiao, Liang-Tsai, Chaou, Shu-Chou, Gau, Jyh-Pyng, Lee, Tzu-Chi, Shih, Ying-Yih, Liu, Chun-Yu, Hong, Ying-Chung, Chen, Ming-Huang, Chang, Mu-Hsin, Yang, Ya-Hsu, Chen, Po-Min |
| Zdroj: |
Journal of Clinical Apheresis; 2007, Vol. 22 Issue 4, p195-203, 9p |
| Abstrakt: |
We developed a model (depending on peripheral CD34+ cell count and hematopoietic progenitor cell count) to determine the optimal timing of 3-day leukapheresis in patients pretreated with chemotherapy and G-CSF. Marrow potentials were identified on the basis of three patterns of leukapheretic yield. Pattern 1 predicted good marrow potential. The positive predictive value of a first-day leukapheretic yield of >1 × 106 CD34+ cells/kg (mean 3-day yield = 8.18 × 106 CD34+ cells/kg, n = 11) was 100%. Pattern 2 predicted poor marrow potential. The negative predictive value of a 3-day leukapheretic yield of >1 × 106 CD34+ cells/kg (3-day yield = 0.26 × 106 CD34+ cells/kg, n = 1) was 100%. Pattern 3 met neither of the above criteria (mean 3-day yield = 1.37 × 106 CD34+ cells/kg, n = 19). The marrow potential was borderline and patients could be further divided into two subgroups according to peripheral CD34+ cell counts when WBC reached >10,000/μl. The mean yield differed significantly between pattern 1 and 3 ( P < 0.001). For patients with good marrow potential, leukapheresis should begin as soon as the WBC count is >5,000/μl. Patients with borderline marrow potential may benefit from delaying leukapheresis until the WBC level is >10,000/μl and leukapheresis extended more than 3 days. J. Clin. Apheresis 2007. © 2007 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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