| Abstrakt: |
The reflection coefficient, σ, for several small permeant nonelectrolytes was determined for dog and beef blood cell membranes. Our σ values were considerably higher than those previously reported for dog cells; e.g., our σ was 87% higher than the σ of Rich, Sha'afi, Barton and Solomon ( J. Gen. Physiol. 50: 2391, 1967). Our σ values for urea were only slightly greater in beef cells than previously reported by Farmer and Macey ( Biochim. Biophys. Acta 290: 290, 1972). We found that a trend exists when (1−σ) is plotted against the log of the permeability coefficient, ω. This observation is also consistent with our previously reported σ data for human red cell membranes (Owen & Eyring, J. Gen. Physiol. 66: 251, 1975). This trend suggests that small hydrophilic molecules interact highly with cell membrane water. The exceptions to this trend were lipophilic molecules, indicating they do not interact with water while penetrating the red cell membrane. [ABSTRACT FROM AUTHOR] |
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