Dietary protein effects on cholelithiasis in hamsters: Interaction with amino acids and bile acids.

Autor: Sullivan-Gorman, M., Anderson, J., DiMarco, N., Johnson, J., Chen, I., Ashby, J., Liepa, G.
Zdroj: Journal of the American Oil Chemists' Society (JAOCS); Aug1987, Vol. 64 Issue 8, p1196-1199, 4p
Abstrakt: The objective of this experiment was to study the effects of dietary cottonseed protein and casein on plasma and biliary lipids, plasma amino acids and gallstones in hamsters. Thirty-four male hamsters (60 ± 5 g) were fed either the lithogenic 'Dam Diet' (containing 20% casein, 74.3% sucrose and 5.7% vitamin-mineral mix) or a similar diet that contained 20% cottonseed protein for 30 days. Both diets contained protein as a protein isolate. The concentration of alpha-aminobutyric acid was significantly elevated in the casein-fed group. Significant differences in the total plasma cholesterol or lipoprotein cholesterol concentrations were not observed between the two dietary groups. A significant elevation in the absolute concentration of biliary cholesterol was observed in the casein-fed hamsters. Cottonseed protein-fed animals exhibited a significantly elevated concentration of bile acids. The ratio of glycochenodeoxycholic:glycocholic acid was significantly higher in the cotton-seed protein-fed group. This study reports that an elevated concentration of biliary cholesterol with a concomitant decrease in bile acid concentration yields a condition favorable to gallstone formation. It is proposed that cottonseed protein may have a specific effect on the bile acid pool by increasing the ratio of glycochenodeoxycholic acid:glycocholic acid which, in turn, prevents formation of cholesterol gallstones. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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