Pancreatic enzyme activities in early life.

Autor: Glasgow, John, Dinsmore, Hilary, Molla, Ayesha
Zdroj: Irish Journal of Medical Science; Dec1980, Vol. 149 Issue 1, p194-200, 7p
Abstrakt: Pancreatic lipase and trypsin have been measured autotitrigraphically in duodenal aspirate both before and for 3 hours after an oral test feed. These studies concern 12 normal newborns, gestational maturity 34±2 weeks (M±SD), at approximately 2 weeks of age, and 14 apparently normal children aged 3-72 months. A consistent pattern of enzyme activity was found, with higher activity in the resting samples and in the third hour compared to very low activity during the first post-prandial hour. There was a significantly higher mean lipase activity in children compared with that in newborns (P=0.001) which was not so for mean trypsin. An estimate of total enzyme secretion by the pancreas was devised using determinations of polyethylene glycol in test feed and duodenal contents; this also allowed intergroup comparison since there was a significant difference between the groups in the degree to which test feed diluted enzyme activity (P<0.01). Mean total lipase activity was significantly higher in children compared to that in newborns (P<0.01); this was not so for trypsin. Children secreted significantly less enzyme activity per unit body weight than newborns, in whom there was a significant correlation between total lipase activity and gestational maturity (r=+0.54; P<0.05), which was not found for trypsin. Trypsin would appear therefore to be relatively mature by the stage of gestation at which our study was done, while lipase matures nearer and to a greater degreee after birth. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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