| Abstrakt: |
A 17-yr-old boy presented with hypospadias and gynecomastia. His secondary sexual characters were poorly developed: small phallus, bilateral atrophic testes, absence of beard and moustache, axillary hair, feminine distribution of public hair and marked enlargement of breats. Laparotomy findings showed absence of ovaries, fallopian tubes and uterus. Histopathology of the testes showed spermatogenic arrest, distorted tubules and epidymis, and very few leydig cells. Cytogenetic studies showed, 45, XY, −13, −14, +t (13q; 14q) karyotype in cultured lymphocytes and gonadal fibroblast culture. His LH, FSH and prolactin hormone levels were within normal range. The case report suggests the possible interaction of autosomal genes in the human sexual development. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink