| Autor: |
Fujita, Masahiro, Takatoku, Keizo, Matoba, Yoshinori, Nishiura, Masaru, Kobayashi, Kaoru, Inoue, Osamu, Nishimura, Tsunehiko |
| Zdroj: |
European Journal of Nuclear Medicine; Apr1996, Vol. 23 Issue 4, p431-436, 6p |
| Abstrakt: |
Iodine-123-labelled 3β-(4-iodophenyl)tropane-2β-carboxylic acid ([I]β-CIT) labels both the dopamine transporter (DAT) and the serotonin transporter (5-HTT) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. However, the differential kinetics of β-CIT binding to DAT and 5-HTT has not been clarified fully. In this study we examined time-activity curves of [I]β-CIT in individual regions in the rat brain. Using cerebellum as the reference region, k and k values were estimated by a two-compartment kinetic analysis. In the striatum, the kinetics was slowest among all brain areas. In this area specific binding reached its peak 4 h after the injection. In the hypothalamus, specific binding reached its peak 1 h after the injection and its amount did not change until 4 h after the injection. In the occipital cortex, the binding and washout of the ligand were fastest among all brain regions. Estimated k values were 0.040±0.003 in the striatum, 0.019±0.002 in the hypothalamus and 0.082±0.011 in the occipital cortex (min, mean ±SD). Estimated k values were 0.0034±0.0005 in the striatum, 0.0071±0.0009 in the hypothalamus and 0.083±0.013 in the occipital cortex (min, mean ±SD). Therefore binding kinetics of [I]β-CIT in the region rich in DAT is apparently different from that in the region rich in 5-HTT. These results will provide fundamental data to image both DAT and 5-HTT in one series of examinations with [I]β-CIT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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