| Autor: |
Babich, John, Keeling, Frank, Flower, Margaret, Repetto, Lazzaro, Whitton, Anthony, Fielding, Sue, Fullbrook, Ann, Ott, Robert, McCready, V. |
| Zdroj: |
European Journal of Nuclear Medicine; Apr1988, Vol. 14 Issue 1, p39-44, 6p |
| Abstrakt: |
A preliminary study of the distribution of the Tc complex of hexamethylpropylene amine oxime (HM-PAO) in 12 patients with brain neoplasms before, during, and after radiotherapy has been performed. Untreated brain tumors were found to exhibit a range of Tc-HM-PAO uptake, varying from areas of markedly increased isotope activity to photopenic areas, when compared to normal brain tissue. A ratio of Tc-HM-PAO tumor uptake to contralateral normal tissue uptake was calculated prior to and during radiotherapy. This ratio tended to return towards unity in lesions responding to therapy. A predictable alteration in whole brain Tc-HM-PAO uptake during radiotherapy was not demonstrated. Unlike the radiolabeled amines, Tc-HM-PAO localizes in primary tumors, probably indicating that its uptake mechanism is independent of non specific amine receptors. Tc-HM-PAO may be useful in the study of brain tumor physiology and response to therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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