| Autor: |
Uğur, Ömer, Kostakoğlu, Lale, Güler, Nilüter, Caner, Biray, Uysal, Uğur, Elahi, Nazenin, Hafloğlu, Mithat, Yüksel, Doğangün, Aras, Tülin, Bayhan, Hikmet, Bekdik, Coşkun |
| Zdroj: |
European Journal of Nuclear Medicine; Oct1996, Vol. 23 Issue 10, p1367-1371, 5p |
| Abstrakt: |
Radionuclide scanning with tumour-seeking agents such as pentavalent technetium-99m dimercaptosuccinic acid [Tc(V)-DMSA], thallium-201 and technetium-99m sestamibi (MIBI) has been reported to be useful in the detection of medullary thyroid carcinoma (MTC). We undertook a study in 14 MTC patients to determine the comparative imaging potential ofTl, MIBI andTc(V)-DMSA in the detection of recurrent or metastatic MTC. All patients underwent total thyroidectomy and had persistently elevated serum calcitonin levels after the surgery. Scintigraphic studies were carried out 20 min after the injection of 111 MBq ofTl or 555 MBq of MIBI and 2 h following the injection of 370 MBq ofTc(V)-DMSA. All scintigraphic findings were correlated with contemporaneous CT or MRI studies. CT, MRI and bone scans showed 42 (26 bone, 16 soft tissue) metastatic sites in 11 of the 14 patients. In the remaining three patients no lesions were detected during diagnostic evaluation.Tc(V)-DMSA showed all of the soft tissue metastases but could not show two bone lesions. On the other hand, MIBI imaging was false-negative in 22 (52%) sites andTl was false-negative in 34 (80%) sites. Overall, lesion detection sensitivities forTc(V)-DMSA, MIBI andTl were 95%, 47% and 19% respectively. We conclude thatTc(V)-DMSA is clearly superior to MIBI andTl in the follow-up of MTC patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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