Beta-2-adrenoceptor agonists as inhibitors of lung vascular permeability to radiolabelled transferrin in the adult respiratory distress syndrome in man.

Autor: Basran, Gurnam, Hardy, John, Woo, Sai, Ramasubramanian, Ramiah, Byrne, Andrew
Zdroj: European Journal of Nuclear Medicine; Nov1986, Vol. 12 Issue 8, p381-384, 4p
Abstrakt: Increased lung vascular permeability leading to increased plasma protein extravasation and accumulation (PPA) is a characteristic feature of acute lung injury. Using a previously described technique, PPA was monitored in the lungs of patients with the adult respiratory distress syndrome (ARDS) - an extreme example of acute lung injury in man. An external radiation probe detector was used to monitor the pulmonary accumulation of the plasma protein transferrin radiolabelled in-vivo with In. Ten patients with ARDS exhibiting increased PPA indices (>1.0x10/min) were given an intravenous infusion of terbutaline (7 μg/kg) over 30 min. Of the four patients in whom the post-drug PPA indices remained within the ARDS range, none survived, whilst five of the six patients in whom the post-drug PPA indices were reduced to below 1.0x10/min survived. PPA indices prior to the administration of terbutaline were not significantly different between the survivor ( n=5) and non-survivor ( n=5) groups. There was a significant decrease in the PPA indices following terbutaline in survivors ( p<0.01) but not in non-survivors. Thus beta-2-agonists in therapeutic doses can inhibit increased lung vascular permeability in man. These findings may have prognostic and therapeutic implication for beta-2-agonists in ARDS. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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