| Autor: |
Hara, Toshihiko, Iio, Masaaki, Izuchi, Rokuro, Tsukiyama, Takashi, Yokoi, Fuji |
| Zdroj: |
European Journal of Nuclear Medicine; Nov1985, Vol. 11 Issue 6/7, p275-278, 4p |
| Abstrakt: |
Pyruvate-1-C was prepared enzymatically by the exchange reaction of CO with the carboxyl group of pyruvic acid using pyruvate-ferredoxin oxidoreductase from Clostridium butyricum. C-Labeled pyruvate was purified by sublimation in specially made glassware. The radiochemical yield of pure pyruvate-1-C was 80% 35 min after the end of bombardment. The distribution of C in tumor-bearing rabbits after an i.v. injection of pyruvate-1-C was observed using a gamma camera. In contrast to normal organs, the tumor was positively visualized. We also conducted a number of successful clinical studies. A case of brain tumor which exhibited a positive image on positron-emission tomography (PET) using pyruvate-1-C is presented. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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