| Autor: |
Köhn, Horst, Klech, Heinrich, Angelberger, Peter, Strigl, Anton, Zolle, Ilse, Kummer, Friedrich, Mostbeck, Adolf |
| Zdroj: |
European Journal of Nuclear Medicine; May1985, Vol. 10 Issue 9/10, p411-416, 6p |
| Abstrakt: |
The production of monodisperse human albumin millimicrospheres (diameter <1 μm) and labeling with Tc is described. A system constructed to nebulize and deliver a dry aerosol yielded a lung delivery efficiency of approximately 25%. In 48 patients without and with varying degrees of chronic obstructive lung disease, quantitative comparison with Kr (penetration index, regional distribution of activity in the lungs) demonstrated similar penetration of the particles to the lung periphery ( r=0.89 and r=0.94, respectively). Qualitative comparison with Kr or Xe showed complete or a high degree of diagnostic agreement in all but one patient. Semiquantitative scoring of hot spots as a substrate of local turbulent airflow showed a close inverse correlation ( r=-0.82) with the forced expiratory volume in 1 s (FEV 1.0%), thus providing additional information about the severity of the airway obstruction. In 24 patients with suspected pulmonary embolism, complete agreement between aerosol and Kr images was found in all patients studied. For same-day ventilation/perfusion studies, labeling of the millimicrospheres with In yielded images of comparable quality to those obtained with the Tc-labeled aerosol. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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