| Autor: |
Ito, Yasuhiko, Nagai, Kazue, Otsuka, Nobuaki, Yamashita, Koshi, Yokobayashi, Tsuneo, Muranaka, Akira, Terashima, Hideaki |
| Zdroj: |
European Journal of Nuclear Medicine; Aug1980, Vol. 5 Issue 4, p357-368, 12p |
| Abstrakt: |
This report is a study of the differential diagnosis of bone diseases using nucleomedical procedures. Experimental and clinical studies on the accumulation of Tl and Ga in bone inflammation and bone tumors were performed. Also, the degree of deposition of Tc-phosphorous compounds represented as a color difference was evaluated for a differentiation between malignant and benign diseases of the spine and shoulder. Uptake of Tl in inflammation of the spine and in tumor of the pelvis of rabbits was very low, while that of Ga was high. Uptake of Ga decreased gradually with lapse of time after the onset of inflammation. These experimental results agreed with clinical studies. The detectability of malignant tumors with Tl was inferior to that with Tc-label and Ga, although osteolytic lesions were occasionally Tl-positive. In terms of color range, the difference was 2 or less in spines of normal subjects and 3 or more in the metastatic bone disease and compression fracture. This difference was not statistically significant. Since Ga scan was occasionally negative in compression fracture, a differentiation was considered to be possible in such a case. A combined study of bone imaging with Tc-phosphorous compound including color difference, Ga imaging, bone-marrow imaging and radiography are considered to be helpful for the differentiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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