Autoradiographic localization of binding sites for H-serotonin and H-ketanserin on neurones and astrocytes of cultured rat brain stem and spinal cord.

Autor: Hösli, E., Hösli, L.
Zdroj: Experimental Brain Research; 1987, Vol. 65 Issue 2, p486-490, 5p
Abstrakt: By means of lightmicroscopic autoradiography we have studied the cellular localization of binding sites for H-serotonin and H-ketanserin in organotypic cultures of rat brain stem and spinal cord. In both types of cultures, a relatively great number of neurones revealed binding sites for H-serotonin which predominantly labels S-receptors. H-ketanserin, an S-antagonist was also bound to many neurones although to a lesser extent than H-serotonin. Binding sites for both radio-ligands were also observed on astrocytes. These findings together with electrophysiological investigations indicate that astrocytes possess serotonin receptors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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