| Abstrakt: |
A description is given of the effect of strychnine on optic evoked potentials in chick embryos. The observations were made on chick embryos aged from the second half of the 17th day till the end of incubation. Strychnine was applied on the surface of the optic lobe in the midbrain. During the second half of the 17th day flash stimulation did not evoke the electric response in the optic lobes in normal embryos, but it occured in some cases after strychninization. In older embryos, in which the evoked response occured regularly, strychnine had a quantitative effect on the parameters of evoked responses (i.e. the latency of the negative spike, its duration and amplitude and the steepness of the crescent and decrescent part of negative spike). The latency of the maxima effect of strychnine lasted about 4 min. The relative increase in amplitude bore on indirect correlation to the age of embryos. The other quantitative changes were also developmentally different. In the morphology of optic evoked potentials strychnine abolished the double-peak at the top of the dominant negative spike. [ABSTRACT FROM AUTHOR] |
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