Indomethacin augmented antitumor activity of 5-fluorouracil in meth-a induced mice.

Autor: Ogino, Mitsuharu
Zdroj: International Journal of Clinical Oncology; Aug1996, Vol. 1 Issue 2, p75-79, 5p
Abstrakt: Background: This study used an ascitic fluid tumor model to assess antitumor effects of indomethacin (INN) and its enhancing effect on the antitumor activity of 5-fluorouracil (5FU). Methods: Each (monotherapy) or both agents (combined therapy) were administered IP to BALB-c mice on alternate days. Antitumor activity was determined by survival of the experimental animals. Results: INN (25 (μg/kg IP) improved the survival of the experimental animals significantly ( P<0.005) when compared to the nonmedicated controls. The INN was shown to augment the antitumor activity of 5FU significantly at doses of 2.5 ( P<0.005) and 10 ( P<0.005) mg/kg IP, compared to 5FU monotherapy at each dose. Carcass weight was significantly higher ( P<0.01-0.05) in the combination therapy groups than in the controls. This effect was the result of a less marked decrease in food intake, although there was no significant difference in carcass weight between single and combined therapies. Conclusion: INN was shown to exert its antitumor effect and to augment the antitumor activity of 5FU which led to the improved survival of mice bearing ascitic tumors. This evidence suggests a potential role for INN as an adjunct to standard chemotherapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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