Immunopathology of acute rheumatic fever and rheumatic heart disease. The demonstration of Coxsackie group B viral antigen in the myocardium.

Autor: Pongpanich, B., Boonpucknavig, S., Wasi, C., Tanphaichitr, P., Boonpucknavig, V.
Zdroj: Clinical Rheumatology; Sep1983, Vol. 2 Issue 3, p217-222, 6p
Abstrakt: Immunopathologic studies were performed on heart tissue of patients with acute rheumatic fever with carditis and chronic rheumatic heart disease. Coxsackie group B viral antigen was demonstrated in 3 heart specimens of patients clinically compatible with active rheumatic fever. In two of these the pathologic findings were compatible with acute rheumatic carditis. Immunoglobulin was detected in 2 and complement in one of these heart specimens. All of the chronic rheumatic heart specimens and the controls were negative. These findings suggested that Coxsackie group B virus may be etiologically related to the pathogenesis of acute rheumatic fever. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index