| Autor: |
Mizukami, Yusuke, Ohhira, Motoyuki, Matsumoto, Akinori, Murazumi, Yukari, Murazumi, Kazuhiko, Ohia, Hitoyoshi, Ohhira, Masumi, Ono, Minoru, Miyake, Takayoshi, Maekawa, Isao, Kohgo, Yutaka |
| Zdroj: |
Journal of Gastroenterology; Mar1996, Vol. 31 Issue 2, p284-288, 5p |
| Abstrakt: |
A case of primary biliary cirrhosis (PBC) associated with idiopathic thrombocytopenic purpura (ITP) is reported. The patient is a 59-year-old man. When he was 49 years old, he was diagnosed with ITP and received steroid therapy that successfully increased platelet numbers. However, the steroid therapy failed to normalize the elevated gamma-glutamyl transpeptidase. Ten years after this episode, he suffered from general itching and malaise and exhibited a gradual increase of serum biliary enzyme levels. Immunologically, IgM was increased and anti-mitochondrial antibody was positive. Histological findings of liver needle biopsy showed chronic non-suppurative destructive cholangitis, confirming the diagnosis of PBC. To date, very few PBC cases associated with ITP have been reported. Our case is the second one in Japan. PBC and ITP in our patient seemed to develop simultaneously, but the effect of steroid therapy on the two conditions was different. This result suggests that the autoimmune process may have been different in PBC and ITP in the present patient. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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