| Abstrakt: |
The authors evaluated the clinical significance of anti-ClOO, anti-GOR and anti-CP9 in hepatitis C virus (HCV)-related liver disease in two populations: 459 healthy subjects and 385 patients with chronic liver disease (CLD). Previously we reported high rates of mortality and morbidity (5.3%) of CLD in subjects in Saga, Japan. This was ascribed to the high prevalence (10.8%) of anti-HCV among randomized populations, as detected by the C100 ELISA test system, as compared with a finding of 2-3% in Japanese blood donors in the same decade. The incidence of anti-ClOO, anti-GOR and anti-CP9 detected by ELISA test system in the healthy population currently surveyed was 17.0%, 19.2% and 32.0% respectively, as compared with 75.3%, 60.3% and 73.0% respectively, in those with CLD. The incidence of positivity for at least one of the three antibodies was high (36.4%) among healthy subjects, and even higher (86.5%) among the patients with CLD. In the healthy subjects, incidence of positivity increased with age. Thé healthy and CLD populations differed in the proportion of cases positive for all three antibodies vs. those positive for at least one antibody: healthy subjects, 52/167, 31.1%, vs. CLD patients, 197/333, 59.2%; P<0.01. Among the anti-C100-positive healthy cases, these was a significantly high level of AST, ALT, ZTT and γ GTP compared with negative cases, with or without anti-GOR and anti-CP9 (P<0.01-0.05). These observations suggest that the presence of anti-ClOO may be related to the active state of HCV-related liver disease. In addition, the presence of anti-GOR and anti-CP9 suggest that the patients is an asymptomatic carrier of HCV or is recovering from an HCV infection. [ABSTRACT FROM AUTHOR] |
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