| Autor: |
Kawada, Norifumi, Mizoguchi, Yasuhiro, Kobayashi, Kenzo, Yamamoto, Sukeo, Morisawa, Seiji |
| Zdroj: |
Journal of Gastroenterology; Jun1990, Vol. 25 Issue 3, p363-368, 6p |
| Abstrakt: |
The changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue of rats with carbon tetrachloride (CCl-induced liver injury were studied. As a result, after the administration of CCI, the levels of LTs increased at an early stage while the levels of PGs increased at a later stage. This suggests that LTs may have an adverse effect on liver injury induced by CC1, and that PGs may not have a direct effect on liver injury. In addition, serum GOT and GPT levels improved with the administration of AA-861, a 5-lipoxygenase inhibitor, while these levels did not change with the administration of indomethacin, a cyclooxygenase inhibitor. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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