| Autor: |
Túri, Sándor, Bereczki, Csaba, Torday, Csilla, Havass, Zoltán, Németh, Márta |
| Zdroj: |
Pediatric Nephrology; May1991, Vol. 5 Issue 3, p327-331, 5p |
| Abstrakt: |
The effects of chronic uraemia and serial acetate (HDA) or bicarbonate (HDB) hacmodialysis on the aggregation, thromboxane B (TXB) release and cyclic AMP (cAMP) concentration of platelets from arterial blood were studied in 14 uraemic patients (6 dialysed and 8 conservatively treated) and 10 controls. Platelets from uraemic patients, either dialysed or treated conservatively, exhibited a significantly higher cAMP level ( P<0.005), a lower TXB level ( P<0.01), and a lower aggregability ( P<0.001) than the controls. The platelet cAMP level was more markedly decreased after HDB than after HDA ( P<0.05). Greater increases in platelet aggregation ( P<0.05) and TXB formation were observed after HDB than after HDA. The concentration of platelet cAMP and aggregability, and also the platelet cAMP and the TXB level showed a significantly negative correlation ( r=−0.7, P<0.05 and r=−0.60, P<0.05, respectively). There was a positive correlation between the platelet-derived TXB and the aggregability ( r=0.67, P<0.05). Although most patients had secondary hyperparathyroidism, the serum parathyroid hormone level did not correlate closely with the cAMP, TXB or aggregation results. The dysfunction of uraemic platelets accompanied by a reduced TXB release may be explained by an increased cAMP and a decreased arachidonic acid availability. HDB improves the platelet function to a greater degree than does HDA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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