Acyclovir-induced renal failure: course and risk factors.

Autor: Bianchetti, Mario, Roduit, Claudio, Oetliker, Oskar
Zdroj: Pediatric Nephrology; Mar1991, Vol. 5 Issue 2, p238-239, 2p
Abstrakt: Of 19 children treated with high-dose intravenous acyclovir, 7, all of whom had encephalitis, also had a restricted fluid intake. Of these, 3 experienced nonoliguric renal insufficiency (plasma creatinine up to 176, 250 and 351 μmol/l, respectively) which resolved within 1 week of discontinuing acyclovir. Renal function was stable in the remaining 4 patients in this group and in the 12 children treated with acyclovir but without fluid restriction. We suggest the decreased renal function resulted from intratubular acyclovir crystalluria. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index