Tropisetron (Navoban) in the prevention of chemotherapy-induced nausea and vomiting--the Nordic experience.

Autor: Sorbe, Bengt, Andersson, Håkan, Schmidt, Margareta, Söderberg, Martin, Högberg, Thomas, Wernstedt, Lars, Janson, Eva, Ehrnström, Bengt, Kjaer, Mogens, Havsteen, Hanne, Overgaard, Maria, Sandberg, Erik, Flander, Martti, Heikkinen, Mirja, Nikkanen, Väinämö, Sorbe, B, Andersson, H, Schmidt, M, Söderberg, M, Högberg, T
Zdroj: Supportive Care in Cancer; Nov1994, Vol. 2 Issue 6, p393-399, 7p
Abstrakt: An open, noncomparative, Nordic multicenter study was carried out during 1991-1992 to evaluate the 5-HT3 receptor antagonist tropisetron (Navoban) as an antiemetic agent for various types of cancer chemotherapy. A total of 630 patients were recruited from 15 centers in Sweden, Denmark, and Finland. Gynecological cancers (60%), breast cancer (15%), and lung cancer (10%) were the main diagnoses. Prior experience of chemotherapy was documented in 338 patients (54%). In 260 patients (41%), cisplatin was part of the cytostatic regimen. Carboplatin (23%), doxorubicin (27%), and epidoxorubicin (24%) were also frequently included. In all, 23 cytostatic agents were used in various combinations. The mean number of courses studied was 4.6 (range 1-19). Altogether, 394 of 619 evaluable patients (64%) were completely protected from acute nausea and vomiting during the first course of chemotherapy. Delayed nausea and vomiting were completely prevented in 45%-73% (days 2-6) in the complete series. Treatment efficacy remained stable (60%-79%) during ten consecutive courses of chemotherapy. With noncisplatin regimens, complete protection from acute nausea and vomiting was achieved in 72% compared with 52% for cisplatin regimens (P < 0.0001). Patients without prior experience of chemotherapy had higher control rates of acute nausea and vomiting (72%) compared to patients treated before (57%) during the first course, but not later on. There were no differences in delayed nausea and vomiting.(ABSTRACT TRUNCATED AT 250 WORDS) [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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