| Autor: |
Janvier, J., Peyraud-Waïtzenegger, M., Soulier, P. |
| Zdroj: |
Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology; Mar1996, Vol. 165 Issue 8, p640-646, 7p |
| Abstrakt: |
The effects of serotonin (5-hydroxytryptamine) on ventilation were investigated by continuous measurements of intrabuccal pressure in unrestrained eel. Intravenous administration of 5-hydroxytryptamine (30 μg·kg) caused a large increase in ventilatory frequency (+100%) and amplitude (+140%). The 5-hydroxytryptamine-induced hyperventilation was blocked by the 5-HT-receptor antagonists metoclopramide (1.0 mg·kg) or MDL72222 (1.0 mg·kg), and was insensitive to the 5-HT-receptor antagonist methysergide (3.0 mg·kg) and to the 5-HT-receptor antagonist DAU 6285 CL (3.0 mg·kg). The hyperventilatory response to 5-hydroxytryptamine could be mimicked by the 5-HT receptor agonist 1-phenylbiguanide (300 μg·kg). These results strongly implicate the 5-HT-receptor as the mediator of the 5-hydroxytryptamine-induced hyperventilation in eel. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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