| Autor: |
Otto, Florian, Mackensen, Andreas, Mertelsmann, Roland, Engelhardt, Rupert |
| Zdroj: |
Cancer Immunology, Immunotherapy; Mar1995, Vol. 40 Issue 2, p115-118, 4p |
| Abstrakt: |
The course of metastatic renal cell carcinoma may be positively influenced by immunotherapeutic agents. We report a case of renal cell carcinoma showing a complete response to once-weekly low-dose s. c. interferon-γ (INFγ) treatment in multiple metastatic sites (lung, chest wall, abdomen, vertebral body), but concomitantly developing a solitary brain metastasis. High initial interleukin-6 (IL-6) levels returned to normal during IFN treatment suggesting that IFNγ may have interrupted an autocrine IL-6/IL-6-receptor loop of the tumor cells. The duration of complete remission in the extracerebral sites is now 46+ months. IFNγ may be less active beyond the blood/brain barrier. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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