Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures.

Autor: Farkas, Ruth, Ben-Efraim, Shlomo, Manor, Yosef, Zan-Bar, Israel, Klajman, Abraham
Zdroj: Cancer Immunology, Immunotherapy; May1991, Vol. 34 Issue 3, p181-185, 5p
Abstrakt: Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index