The stability of mesna in beverages and syrup for oral administration.

Autor:	Goren, Marshall, Lyman, Beverly, Li, Jackie, Goren, M P, Lyman, B A, Li, J T
Předmět:	SULFUR compounds analysis BEVERAGES COLORIMETRY COMPARATIVE studies DRUG stability DRUG storage RESEARCH methodology MEDICAL cooperation ORAL drug administration RESEARCH RESEARCH funding SOLUTION (Chemistry) SULFUR compounds SYRINGES TIME EVALUATION research
Zdroj:	Cancer Chemotherapy & Pharmacology; Jul1991, Vol. 28 Issue 4, p298-301, 4p
Abstrakt:	We evaluated the stability of the aqueous formulation of mesna during storage in syringes and after dilution in beverages and syrups. Measurements of the concentrations of mesna showed that the undiluted formulation was stable for at least 9 days in standard polypropylene syringes at 5 degrees, 24 degrees, and 35 degrees C. There was no detectable oxidation of mesna to dimesna over the course of at least 1 week when mesna was diluted 1:2 and 1:5 in syrups and incubated at 24 degrees C in capped tubes. Concentration changes were clinically negligible for 1:2, 1:10, and 1:100 dilutions of mesna in six carbonated drinks, two juices, and milk after incubation for 24 h at 5 degrees C. Thus, the aqueous mesna formulation is stable when diluted and stored in a variety of beverages and syrups under conditions suitable for oral administration. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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