Synthesis and antitumor activity of a platinum (II)-doxorubicin complex.

Autor: Zunino, Franco, Savi, Giuseppina, Pasini, Alessandro
Zdroj: Cancer Chemotherapy & Pharmacology; Nov1986, Vol. 18 Issue 2, p180-182, 3p
Abstrakt: A mixed platinum (II) complex with tert-butylamine and doxorubicin (cooordinated via the aminogroup) has been synthesized and tested for antitumor activity. The results indicate that the complex was active against doxorubibin-resistant P388 and cisplatin-resistant L1210 leukemias, while maintaining antitumor activity against sensitive parent lines. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index