Potentiation of antitumor activity of 1-phthalidyl 5-fluorouracil by acetazolamide.

Autor:	Kasai, Hisanori, Tonda, Kanya, Hirata, Masaharu, Kasai, H, Tonda, K, Hirata, M
Předmět:	ACETAZOLAMIDE ANIMAL experimentation ANTINEOPLASTIC agents DRUG synergism FLUOROURACIL RATS SARCOMA PHARMACODYNAMICS
Zdroj:	Cancer Chemotherapy & Pharmacology; Jan1986, Vol. 16 Issue 1, p55-57, 3p
Abstrakt:	The effect of acetazolamide (A.A.) on the antineoplastic activity of 1-phthalidyl 5-fluorouracil (PH-FU) against rat and mouse solid tumors was examined. A.A., an inhibitor of liver PH-FU hydrolase, had no antitumor activity but greatly enhanced the activity of PH-FU when coadministered. The potentiation was evaluated in terms of suppression of tumor growth and prolongation of the life-span of tumor-bearing animals. Studies also revealed that A.A. elevated the concentration of PH-FU in tumor tissues, where 5-fluorouracil is slowly liberated from PH-FU. The results are consistent with the hypothesis that A.A. prevents enzymic degradation of PH-FU in the liver and promotes its distribution into target organs. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink