| Autor: |
Jackson, Don, Chauvenet, Allen, Callahan, Richard, Atkins, James, Trahey, Thomas, Spurr, Charles, Jackson, D V Jr, Chauvenet, A R, Callahan, R D, Atkins, J N, Trahey, T F, Spurr, C L |
| Předmět: |
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| Zdroj: |
Cancer Chemotherapy & Pharmacology; Jan1985, Vol. 14 Issue 1, p26-29, 4p |
| Abstrakt: |
A phase II trial of prolonged IV infusions of vincristine was conducted in 21 patients with refractory acute leukemia. Patients received 0.25-0.50 mg/m2 by infusion daily for 5 days after an initial 0.5-mg bolus. A partial response was observed in one of two patients with acute lymphoblastic leukemia. Of 14 patients with acute nonlymphoblastic leukemia, a complete response lasting for 2.5 months occurred in one patient and a partial response lasting 1.3 months was observed in a second. No objective responses were noted in five patients with blast crisis of chronic granulocytic leukemia. Nonhematologic toxicity was minimal and, when present, generally consisted of a feeling of weakness; constipation, mucositis, and areflexia were also observed. Hematologic toxicity consisted mainly of mild to moderate reduction of platelets in most patients; marked thrombocytopenia (less than 50,000/mm3) occurred in two patients whose pretreatment platelet count was greater than 100,000/mm3. Although generally well tolerated, prolonged infusion of vincristine appears to have limited activity in the treatment of refractory acute nonlymphoblastic leukemia and blast crisis of chronic granulocytic leukemia; further evaluation is needed in acute lymphoblastic leukemia refractory to conventional bolus injection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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