| Autor: |
Ehninger, Gerhard, Proksch, Barbara, Hartmann, Franz, Gärtner, Hermine-Valeria, Wilms, Klaus, Ehninger, G, Proksch, B, Hartmann, F, Gärtner, H V, Wilms, K |
| Zdroj: |
Cancer Chemotherapy & Pharmacology; Jan1984, Vol. 12 Issue 1, p50-52, 3p |
| Abstrakt: |
The hepatobiliary pharmacokinetics of mitoxantrone, a new anthracenedione derivative, was studied in the isolated perfused rat liver. Mitoxantrone was administered in doses of 0.2 and 0.4 mg/kg body weight. Multiple bile samples were obtained for 4 hours. Mitoxantrone and three metabolites were separated by high-performance thin-layer chromatography (HPTLC) and measured at 610 nm. Following 0.2 mg mitoxantrone/kg body wt, 25.8% +/- 2.6% of the administered dose was excreted in the bile during 4 h, the major metabolite M1 accounting for 80% of this. After 0.4 mg mitoxantrone/kg body wt the amounts excreted were lower and light microscopic examination showed disseminated areas of cell necrosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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