| Autor: |
Lister, T., Cullen, M., Brearley, R., Beard, M., Stansfeld, A., Whitehouse, J., Wrigley, P., Ford, J., Malpas, J., Crowther, D., Lister, T A, Cullen, M H, Brearley, R B, Beard, M E, Stansfeld, A G, Whitehouse, J M, Wrigley, P F, Ford, J M, Malpas, J S |
| Předmět: |
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| Zdroj: |
Cancer Chemotherapy & Pharmacology; Jun1978, Vol. 1 Issue 2, p107-112, 6p |
| Abstrakt: |
Thirty previously untreated adults with diffuse histiocytic and diffuse undifferentiated lymphoma were treated with a combination of adriamycin, vincristine, prednisolone, and L-asparaginase. Complete remission was achieved in 11 out of 12 cases with stage III and 7 out of 18 cases with stage IV disease (P less than 0.005). Bone marrow infiltration, clinical central nervous system involvement, and massive intra-abdominal disease all influenced the prognosis adversely. Complete remission was followed by cranial irradiation and intrathecal methotrexate, and maintained with weekly cyclophosphamide and methotrexate and daily 6-mercaptopurine. The duration of remission was significantly longer for patients with stage III disease (the median of which has not been reached), than for patients with stage IV disease (P = 0.007). Survival was significantly longer for patients in whom complete remission was achieved than for those in whom it was not (P = 0.001), and also for patients with stage III than for those with stage IV disease (P = 0.02). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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