| Autor: |
Takahashi, Makoto, Fujimoto, Shigeru, Takai, Mitsuru, Ohno, Kazuhide, Endoh, Fumio, Masuda, Yoshio, Masuda, Yoshinori, Obata, Goroh |
| Zdroj: |
Surgery Today; Jan1992, Vol. 22 Issue 1, p35-39, 5p |
| Abstrakt: |
Lymphocyte subpopulations of the spleen were assayed in 26 patients with gastric cancer and 5 patients with benign disease using two-color flow cytometric analysis. The ratio of Leu 2a+·Leu 15+ cells, or suppressor T cells, in the gastric cancer patients was about 6 per cent, being higher than that in the patients with benign disease (p<0.05). There were fewer Leu 7+·Leu 11− cells, or natural killer-NK-cells, in the gastric cancer patients in stage III or IV than in those with stages I or II (p<0.05). The ratio of Leu 3a+·Leu 8− cells, or helper T cells, in the stage IV patients accounted for about 15 per cent of the splenic lymphocytes, which was less than that seen in the patients in stages I or II (p<0.05). The ratio of Leu 2a+·Leu 15− cells, or cytotoxic T cells, was approximately twice that of suppressor T cells. The pre-operative administration of lentinan plus OK-432 increased the ratio of Leu 4+·HLA-DR+ cells, or activated T cells, and cytotoxic T cells (p<0.05 and p<0.01, respectively). The above results suggest that lymphocyte subpopulations in the spleen may have more immuno-suppressive potential in proportion with the stage of gastric cancer, but that this reduced immune state may be altered when lentinan and OK-432 are given to these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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