Mechanism of recovery from acute virus infection II. Effect of treatment of mice with cyclosporin A on their ability to eliminate the lymphocytic choriomeningitis virus.

Autor: Löliger, C., Lehmann-Grube, F.
Zdroj: Medical Microbiology & Immunology; Oct1985, Vol. 174 Issue 4, p187-196, 10p
Abstrakt: Illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin A (CSA), although the virus multiplied extensively in all major organs. Concentrations remained high as long as the drug was administered but declined when the treatment was discontinued; also, cytotoxic T lymphocytes appeared. Virus elimination was slower and cytotoxic T cell activity lower than in mice not previously treated with CSA. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: