The effect of metabolic regulation on microvascular permeability to small and large molecules in short-term juvenile diabetics.

Autor: Parving, H., Noer, I., Deckert, T., Evrin, P., Nielsen, S., Lyngsøe, J., Mogensen, C., Rørth, M., Svendsen, P., Trap-Jensen, J., Lassen, N.
Zdroj: Diabetologia; May1976, Vol. 12 Issue 2, p161-166, 6p
Abstrakt: The microvascular permeability to small and large molecules was studied during good and poor metabolic regulation in ten short duration juvenile diabetics. The following variables were measured; daily urinary albumin and β-microglobulin-excretion rates, whole body transcapillary escape rate of albumin (TER), glomerular filtration rate (GFR), capillary filtration coefficient (CFC), and capillary diffusion capacity (CDC). The urinary albumin and β-microglobulin concentration were measured by sensitive radioimmunoassays; TER was determined from the initial disappearance of intravenously injected I-labelled human serum albumin; GFR was measured by single shot Cr-EDTA clearance; CFC was measured on the forearm by straingauge plethysmography and CDC for Cr-EDTA was determined in the hyperaemic anterior tibial muscle by the local clearance technique. All the above mentioned variables, except CDC, were significantly increased during poor metabolic regulation, indicating a functional microangiopathy. The mechanisms of these alterations appear to be increased filtration pressure in the microcirculation and/or increased porosity of the microvasculature. The findings of increased microvascular albumin passage are compatible with the hypothesis that the organic - histologically demonstrated - diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i. e. the concept of plasmatic vasculosis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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