| Autor: |
Paul, Pradip, O'Byrne, Elizabeth, Blancuzzi, Vincent, Wilson, Douglas, Gunson, Diane, Douglas, Frank, Zhao Wang, Jin, Mezrich, Reuben, Paul, P K, O'Byrne, E, Blancuzzi, V, Wilson, D, Gunson, D, Douglas, F L, Wang, J Z, Mezrich, R S |
| Zdroj: |
Skeletal Radiology; Jan1991, Vol. 20 Issue 1, p31-36, 6p |
| Abstrakt: |
Cartilage degeneration in osteoarthritis is initiated by a loss of proteoglycan. Intra-articular injection of papain causes a reversible loss of proteoglycan in rabbit knees. Rabbits were scanned with magnetic resonance imaging (MRI), using a 1.5T Signa superconducting magnet with 3 inch surface coil. Spin echo sequences were performed in the coronal and sagittal planes at 0, 24, 48, and 72 h after intra-articular injection of papain to obtain T1, proton density, and T2-weighted images. Cartilage proteoglycan content was measured biochemically and histochemically. Reduced articular cartilage thickness in the MR images of papain-treated knees corresponded to changes in cartilage proteoglycan content. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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