| Autor: |
Habib, F., Bissas, A., Neill, W., Busuttil, A., Chisholm, G. |
| Zdroj: |
Urological Research; Jul1989, Vol. 17 Issue 4, p239-243, 5p |
| Abstrakt: |
Flow cytometry of 20 prostate cancer specimens was carried out and the percentage DNA content in each phase of the cell cycle was correlated to the 5α-reductase activity of the tumour. A group of 20 hyperplastic specimens was also entered into this study as control. Tumours were divided into 3 groups on the basis of their 5α-reductase activity. This classification made it possible to identify a group of tumours of which none formed metastases Idiploid tumours with 5α-reductase activity greater than 20 pmol/mg protein/ 30 min and with less than 10% of the cells undergoing mitosis and a second group of which 78% had metastasised at the time of presentation (diploid tumours with 5α-reductase activity less than 10 pmol/mg protein/30 min and with more than 15% of the cells undergoing mitosis). DNA content within each of the 5α-reductase groups appeared also to correlate with the histological grade of the cancer but no relationship was established with the stage of the disease. Our results suggest that a multi factorial discriminant combining DNA ploidy and 5α-reductase measurements offers a good prognostic index for the assessment of disease progression in prostate cancer and that this might form the basis of a new approach to the treatment of this disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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